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Dr Audrey Cooke talks through diagnosing Cushing’s disease using clinical signs, routine blood work, and specific blood testing. Firstly, Dr Cooke runs through what to look out for during physical examination and history that might suggest hyperadrenocorticism.
Routine biochemistry and haematology can support a suspicion of Cushings – we hear how glucose, ALP, phosphorous and cholesterol are often affected. Dr Cooke discusses how none of the tests we currently have for Cushing’s are particularly good. She describes the advantages and disadvantages of using the ACTH stimulation test, Low Dose Dexamethasone Suppression Test, and Urine Cortisol:Creatinine ratio to reach a diagnosis.